Dynemicin, Uncialamycin and Analogues by Daniel Best read online ebook PDF, MOBI, FB2
9780081010860 English 0081010869 Dynemicin A, Uncialamycin and Analogues describes the isolation of dynemicin and uncialamycin, provides a brief overview of their biological activities (and potential development as drugs), and presents the various synthetic routes to prepare these compounds as well as analogues. Dynemicin, uncialamycin, and anthraquinonic derivatives are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. One of the main strengths of this topic is the coverage of a complete field of organic chemistry at the interface with biological science. This ranges from the isolation to the synthesis of natural products (and analogues) possessing enediyne and anthraquinone moieties via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds, Dynemicin, Uncialamycin and Analogues, Dynemicin, Uncialamycin, and anthraquinonic derivatives are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. The purpose of this book is to describe the isolation of Dynemicin and Uncialamycin, to provide a brief overview of their biological activities (and potential development as drugs) and to present the various synthetic routes to prepare these compounds as well as analogues. One of the main strengths of this topic is the coverage of a complete field of organic chemistry at the interface with biological science. This ranges from the isolation to the synthesis of natural products (and analogues) possessing enediyne and anthraquinone moieties via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished, Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity. The total syntheses of dynemicin A, the uncialamycine, as well as analogs are described by emphasizing the synthesis strategies adopted. Featuring studies of the biological activities and data to bring out the structural elements of these essential compounds in these activities., Dynemicin, Uncialamycin, anthraquinonic derivatives, are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. The purpose of this book is to describe the isolation of Dynemicin and Uncialamycin, to provide a brief overview of their biological activities (and potential development as drugs) and to present the various synthetic route to prepare these compounds as well as analogues. One of the main strenghs of this topic is the coverage of a complete field of the organic chemistry at the interface with biological science. This ranges from the isolation to the systhesis of natural products (and analogues) possessing an enediymeand anthraquinone moietis via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished, Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity. The total syntheses of dynemicin A, the uncialamycine, as well as analogs are described by emphasizing the synthesis strategies adopted. Featuring studies of the biological activities and data to bring out the structural elements of these essential compounds in these activities., Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds
9780081010860 English 0081010869 Dynemicin A, Uncialamycin and Analogues describes the isolation of dynemicin and uncialamycin, provides a brief overview of their biological activities (and potential development as drugs), and presents the various synthetic routes to prepare these compounds as well as analogues. Dynemicin, uncialamycin, and anthraquinonic derivatives are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. One of the main strengths of this topic is the coverage of a complete field of organic chemistry at the interface with biological science. This ranges from the isolation to the synthesis of natural products (and analogues) possessing enediyne and anthraquinone moieties via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds, Dynemicin, Uncialamycin and Analogues, Dynemicin, Uncialamycin, and anthraquinonic derivatives are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. The purpose of this book is to describe the isolation of Dynemicin and Uncialamycin, to provide a brief overview of their biological activities (and potential development as drugs) and to present the various synthetic routes to prepare these compounds as well as analogues. One of the main strengths of this topic is the coverage of a complete field of organic chemistry at the interface with biological science. This ranges from the isolation to the synthesis of natural products (and analogues) possessing enediyne and anthraquinone moieties via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished, Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity. The total syntheses of dynemicin A, the uncialamycine, as well as analogs are described by emphasizing the synthesis strategies adopted. Featuring studies of the biological activities and data to bring out the structural elements of these essential compounds in these activities., Dynemicin, Uncialamycin, anthraquinonic derivatives, are natural compounds wtih potent antibacterial and anticancer activities due to their unique enediyne moiety. The purpose of this book is to describe the isolation of Dynemicin and Uncialamycin, to provide a brief overview of their biological activities (and potential development as drugs) and to present the various synthetic route to prepare these compounds as well as analogues. One of the main strenghs of this topic is the coverage of a complete field of the organic chemistry at the interface with biological science. This ranges from the isolation to the systhesis of natural products (and analogues) possessing an enediymeand anthraquinone moietis via their biological activities. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished, Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity. The total syntheses of dynemicin A, the uncialamycine, as well as analogs are described by emphasizing the synthesis strategies adopted. Featuring studies of the biological activities and data to bring out the structural elements of these essential compounds in these activities., Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds