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9781119945499 English 1119945496 Mixed modelling is now well established as a powerful approach to statistical data analysis. This book leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts., Mixed modelling is very useful, and easier than you think Mixed modelling is now well established as a powerful approach to statistical data analysis. It is based on the recognition of random-effect terms in statistical models, leading to inferences and estimates that have much wider applicability and are more realistic than those otherwise obtained. Introduction to Mixed Modelling leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts. Like the first edition, this new edition shows diverse applications of mixed models, provides guidance on the identification of random-effect terms, and explains how to obtain and interpret best linear unbiased predictors (BLUPs). It also introduces several important new topics, including the following: Use of the software SAS, in addition to GenStat and R. Meta-analysis and the multiple testing problem. The Bayesian interpretation of mixed models. Including numerous practical exercises with solutions, this book provides an ideal introduction to mixed modelling for final year undergraduate students, postgraduate students and professional researchers. It will appeal to readers from a wide range of scientific disciplines including statistics, biology, bioinformatics, medicine, agriculture, engineering, economics, archaeology and geography. Praise for the first edition: "One of the main strengths of the text is the bridge it provides between traditional analysis of variance and regression models and the more recently developed class of mixed models...Each chapter is well-motivated by at least one carefully chosen example...demonstrating the broad applicability of mixed models in many different disciplines...most readers will likely learn something new, and those previously unfamiliar with mixed models will obtain a solid foundation on this topic."-- Kerrie Nelson University of South Carolina, in American Statistician, 2007, Mixed modelling is very useful, and easier than you think! Mixed modelling is now well established as a powerful approach to statistical data analysis. It is based on the recognition of random-effect terms in statistical models, leading to inferences and estimates that have much wider applicability and are more realistic than those otherwise obtained. Introduction to Mixed Modelling leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts. Like the first edition, this new edition shows diverse applications of mixed models, provides guidance on the identification of random-effect terms, and explains how to obtain and interpret best linear unbiased predictors (BLUPs). It also introduces several important new topics, including the following: Use of the software SAS, in addition to GenStat and R. Meta-analysis and the multiple testing problem. The Bayesian interpretation of mixed models. Including numerous practical exercises with solutions, this book provides an ideal introduction to mixed modelling for final year undergraduate students, postgraduate students and professional researchers. It will appeal to readers from a wide range of scientific disciplines including statistics, biology, bioinformatics, medicine, agriculture, engineering, economics, archaeology and geography. Praise for the first edition: "One of the main strengths of the text is the bridge it provides between traditional analysis of variance and regression models and the more recently developed class of mixed models...Each chapter is well-motivated by at least one carefully chosen example...demonstrating the broad applicability of mixed models in many different disciplines...most readers will likely learn something new, and those previously unfamiliar with mixed models will obtain a solid foundation on this topic."-- Kerrie Nelson University of South Carolina, in American Statistician, 2007, This book first introduces the criterion of REstricted Maximum Likelihood (REML) for the fitting of a mixed model to data before illustrating how to apply mixed model analysis to a wide range of situations, how to estimate the variance due to each random-effect term in the model, and how to obtain and interpret Best Linear Unbiased Predictors (BLUPs) estimates of individual effects that take account of their random nature. It is intended to be an introductory guide to a relatively advanced specialised topic, and to convince the reader that mixed modelling is neither so specialised nor so difficult as it may at first appear. This edition presents new material in the following areas: Use of mixed models for meta-analysis of a set of experiments, especially clinical trials. The Bayesian interpretation of best linear unbiased predictors (BLUPs). The multiple-testing problem and the shrinkage of BLUPs as a defence against the 'Winner's Curse'. The implementation of mixed models in the statistical software SAS. Increasing the precision of significance tests in mixed models, by estimation of the denominator degrees of freedom (the Kenward-Roger method). Tests for comparison of non-nested mixed models, using the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC).
9781119945499 English 1119945496 Mixed modelling is now well established as a powerful approach to statistical data analysis. This book leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts., Mixed modelling is very useful, and easier than you think Mixed modelling is now well established as a powerful approach to statistical data analysis. It is based on the recognition of random-effect terms in statistical models, leading to inferences and estimates that have much wider applicability and are more realistic than those otherwise obtained. Introduction to Mixed Modelling leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts. Like the first edition, this new edition shows diverse applications of mixed models, provides guidance on the identification of random-effect terms, and explains how to obtain and interpret best linear unbiased predictors (BLUPs). It also introduces several important new topics, including the following: Use of the software SAS, in addition to GenStat and R. Meta-analysis and the multiple testing problem. The Bayesian interpretation of mixed models. Including numerous practical exercises with solutions, this book provides an ideal introduction to mixed modelling for final year undergraduate students, postgraduate students and professional researchers. It will appeal to readers from a wide range of scientific disciplines including statistics, biology, bioinformatics, medicine, agriculture, engineering, economics, archaeology and geography. Praise for the first edition: "One of the main strengths of the text is the bridge it provides between traditional analysis of variance and regression models and the more recently developed class of mixed models...Each chapter is well-motivated by at least one carefully chosen example...demonstrating the broad applicability of mixed models in many different disciplines...most readers will likely learn something new, and those previously unfamiliar with mixed models will obtain a solid foundation on this topic."-- Kerrie Nelson University of South Carolina, in American Statistician, 2007, Mixed modelling is very useful, and easier than you think! Mixed modelling is now well established as a powerful approach to statistical data analysis. It is based on the recognition of random-effect terms in statistical models, leading to inferences and estimates that have much wider applicability and are more realistic than those otherwise obtained. Introduction to Mixed Modelling leads the reader into mixed modelling as a natural extension of two more familiar methods, regression analysis and analysis of variance. It provides practical guidance combined with a clear explanation of the underlying concepts. Like the first edition, this new edition shows diverse applications of mixed models, provides guidance on the identification of random-effect terms, and explains how to obtain and interpret best linear unbiased predictors (BLUPs). It also introduces several important new topics, including the following: Use of the software SAS, in addition to GenStat and R. Meta-analysis and the multiple testing problem. The Bayesian interpretation of mixed models. Including numerous practical exercises with solutions, this book provides an ideal introduction to mixed modelling for final year undergraduate students, postgraduate students and professional researchers. It will appeal to readers from a wide range of scientific disciplines including statistics, biology, bioinformatics, medicine, agriculture, engineering, economics, archaeology and geography. Praise for the first edition: "One of the main strengths of the text is the bridge it provides between traditional analysis of variance and regression models and the more recently developed class of mixed models...Each chapter is well-motivated by at least one carefully chosen example...demonstrating the broad applicability of mixed models in many different disciplines...most readers will likely learn something new, and those previously unfamiliar with mixed models will obtain a solid foundation on this topic."-- Kerrie Nelson University of South Carolina, in American Statistician, 2007, This book first introduces the criterion of REstricted Maximum Likelihood (REML) for the fitting of a mixed model to data before illustrating how to apply mixed model analysis to a wide range of situations, how to estimate the variance due to each random-effect term in the model, and how to obtain and interpret Best Linear Unbiased Predictors (BLUPs) estimates of individual effects that take account of their random nature. It is intended to be an introductory guide to a relatively advanced specialised topic, and to convince the reader that mixed modelling is neither so specialised nor so difficult as it may at first appear. This edition presents new material in the following areas: Use of mixed models for meta-analysis of a set of experiments, especially clinical trials. The Bayesian interpretation of best linear unbiased predictors (BLUPs). The multiple-testing problem and the shrinkage of BLUPs as a defence against the 'Winner's Curse'. The implementation of mixed models in the statistical software SAS. Increasing the precision of significance tests in mixed models, by estimation of the denominator degrees of freedom (the Kenward-Roger method). Tests for comparison of non-nested mixed models, using the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC).